Recommendations
|
Sr.no. |
Recommendations |
||
|---|---|---|---|
|
1 |
We suggest against using thiopurine monotherapy to induce remission in patients with moderately severe CD |
||
| Evidence for Recommendation 1 | |||
|
2 |
We suggest against using methotrexate to induce remission in patients with moderately severe CD |
Weak |
|
| Evidence for Recommendation 2 | |||
|
3 |
We recommend using anti–TNF-α drugs to induce remission in patients with moderately severe CD |
Mod |
|
| Evidence for Recommendation 3 | |||
|
4 |
We recommend using anti–TNF-α monotherapy over thiopurine monotherapy to induce remission in patients who have moderately severe CD |
Strong |
Mod |
| Evidence for Recommendation 4 | |||
|
5 |
We recommend using anti–TNF-α drugs in combination with thiopurines over thiopurine monotherapy to induce remission in patients who have moderately severe CD |
Strong |
|
| Evidence for Recommendation 5 | |||
|
6 |
We suggest using anti–TNF-α drugs in combination with thiopurines over anti–TNF-α drug monotherapy to induce remission in patients who have moderately severe CD |
Weak |
Mod |
| Evidence for Recommendation 6 | |||
|
7 |
We recommend using thiopurines over no immunomodulator therapy to maintain a corticosteroid-induced remission in patients with CD |
Strong |
Mod |
| Evidence for Recommendation 7 | |||
|
8 |
We suggest using methotrexate over no immunomodulator therapy to maintain corticosteroid-induced remission in patients with CD |
Weak |
Low |
| Evidence for Recommendation 8 | |||
|
9 |
We recommend using anti–TNF-α drugs over no anti–TNF-α drugs to maintain corticosteroid- or anti–TNF-α —induced remission in patients with CD |
Strong |
High |
| Evidence for Recommendation 9 | |||
|
10 |
We make no recommendation for or against the combination of an anti–TNF-α drug and a thiopurine versus an anti–TNF-α drug alone to maintain remission induced by a combination of these drugs in patients with CD |
Low |
|
| Evidence for Recommendation 10 | |||
SoR: Strength of Recommendation
QoE: Quality of Evidence
Strong: Strong Recommendation
Weak: Weak Recommendation
N/A: Not Applicable
High: High-Quality Evidence
Mod: Moderate-Quality Evidence
Low: Low-Quality Evidence
CD: Crohn's disease
TNF: Tumor necrosis factor